The US continues to rank #1/11 in health care spending and #11/11 in healthcare performance. We consistently pay more for less health. The Goshua Lab fuses state-of-the-art in quantitative decision science with clinical expertise to address this value lost, with a particular focus on rare hematologic-oncologic diseases. Our analytic lens includes both conventional value (i.e., cost-benefit) and equity-informed analyses to inform stakeholders’ decision-making on resource allocation in health care.