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Leveraging Data to Improve Clinical Care

Goshua Lab at Yale School of Medicine

Abstract Futuristic Background

Goshua Lab at Yale School of Medicine

Leveraging Data to Improve Clinical Care

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Our Collaborators

We are the spoke of a collaborative research hub that include experts from leading health care institutions around the world.

Aligning Clinical Diagnostic and Treatment Strategies with Conventional and Distributional Value to Improve Health Care Performance

The US continues to rank #1/11 in health care spending and #11/11 in healthcare performance. We consistently pay more for less health. The Goshua Lab fuses state-of-the-art in quantitative decision science with clinical expertise to address this value lost, with a particular focus on hematologic-oncologic diseases. Our analytic lens includes both conventional value (i.e., cost-benefit) and distributional impact (i.e., socioeconomic status, geographic region) analyses to inform stakeholders’ decision-making on resource allocation in health care.

Our Work

Source: Mirror, Mirror 2021: Reflecting Poorly, The Commonwealth Fund

Selected Recognitions

Our work has been recognized by premier national organizations and conferences

#1

Most cited original research manuscript in
The Lancet Hematology (>1,000 citations)

20

Oral Presentations 
(17 ASH, 1 EHA, 2 SMDM)

#1

Trending manuscript globally on PubMed (Blood)

3

ASH Press Program Selections
(from >5000 abstracts)

Recent Updates

Next Gen awarded at the American Society of Hematology Meeting

December

2024

Next Gen awarded at the American Society of Hematology Meeting

December

2023

Global recognition: NOMIS Foundation and Editors of Science Magazine

November

2023

Cost-effectiveness of ferritin screening thresholds for iron deficiency in reproductive-age women

Wang D, Sra M, Glaeser-Khan S, Wang DY, Moshashaian-Asl R, Ito S, Cuker A, Goshua G

American Journal of Hematology

2025
April
FEATURED

Gap: First cost-effectiveness analysis of ferritin screening thresholds in the care of people living with iron deficiency (Yale-Mayo-University of Vermont-Penn collaboration). 2024 ASH Press Program Selection, 2025 Highlights of ASH, ASH Abstract Achievement Award (D. Wang). 

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Cost-effectiveness of iptacopan for paroxysmal nocturnal hemoglobinuria

Ito S*, Chetlapalli K*, Wang D, Potnis KC, Richmond R, Krumholz H, Lee AI, Cuker A, Goshua G. 

Blood

2025
January
FEATURED

Gap: Proximal complement inhibition is cost-saving for patients with suboptimal response on C5 inhibitor therapy in the United States and can be cost-saving in international jurisdictions (Penn-Yale collaboration).

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Cost-effectiveness of bevacizumab in the care of patients with hereditary hemorrhagic telangiectasia

Wang D, Ito S, Waldron C, Butt A, Zhang E, Krumholz HM, Al-Samkari H, Goshua G.

Blood Advances

2024
June
FEATURED

Gap: Decreasing the need for hospital, emergency, and procedural care with the use of bevacizumab (vs no bevacizumab) improves quality-adjusted life expectancy and saves costs in the care of people living with HHT (MGH-Yale collaboration). ASH Abstract Achievement Award, Best of ASH (HTRS) (D. Wang)

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Prophylactic weekly efanesoctocog alfa versus standard-care factor VIII in people living with severe hemophilia A: a cost-effectiveness analysis

Ito S, Potnis KC, Harvey JP, Sra M, Bewersdorf JP, Bona RD, Krumholz HM, Cuker A, Pandya A, Goshua G

Annals of Internal Medicine

2025
April
FEATURED

Gap: First conventional-distributional cost-effectiveness analysis in the care of people living with hemophilia A (Yale-HSPH-Mayo-Penn collaboration). ASH Abstract Achievement Award (S. Ito). 

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Decreasing alloimmunization-specific mortality in sickle cell disease in the United States: Cost-effectiveness of a shared transfusion resource

American Journal of Hematology

2024
April
FEATURED

Featured Publications

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